$ALZ
OpenAlz
Dead-End Ledger
Ledger #0013BELOW BAR

HMGCR

viability 0.43 is under the 0.55 bar

Genetics0.00
Brain cell0.50
Druggability1.00
Trial record0.96
Novelty0.49
Pathways0.20

viability · bar 0.550.43

Would flip the verdict

  • human genetics above 0.30 (Open Targets)
  • a Reactome pathway tied to known Alzheimer's biology
seal a58655a95f#0012sealed ✓

11 Oct, 16:43 UTC

Ledger entry #0013

HMGCR was logged as a dead end: viability 0.43 is under the 0.55 bar. The seal is a SHA-256 digest of every field in this entry plus the seal of the entry before it, so changing or deleting any entry would visibly break the chain.

seal
a58655a95fb49683a931bc92d386351f94062daa3950cd294a85533b081ac204
chained to (previous seal)
4123b35d970dd8fc74e4ffa1cbf14ae53c7819c2d28588e2970c3347f3e6dbd9
re-computed by your browser
matches ✓
next entry chains to this seal
yes ✓
#0012#0014 Scout a target