Dead-End Ledger

Negative results, sealed.

Every target that missed the 0.55 viability bar, failed to resolve, or lost a source mid-scout, with the evidence that would flip the verdict. Entries are chained by SHA-256 seals that your browser re-verifies on this page.

15 dead ends logged 15/15 seals re-verified by your browser 14/14 chain links intact

Ledger #0015BELOW BAR

FOXO3

viability 0.44 is under the 0.55 bar

Genetics0.00

Brain cell0.50

Druggability0.60

Trial record1.00

Novelty0.53

Pathways0.55

viability · bar 0.550.44

Would flip the verdict

human genetics above 0.30 (Open Targets)

11 Oct, 16:45 UTC

Ledger #0014BELOW BAR

FOXO3

viability 0.44 is under the 0.55 bar

Genetics0.00

Brain cell0.50

Druggability0.60

Trial record1.00

Novelty0.53

Pathways0.55

viability · bar 0.550.44

Would flip the verdict

human genetics above 0.30 (Open Targets)

11 Oct, 16:43 UTC

Ledger #0013BELOW BAR

HMGCR

viability 0.43 is under the 0.55 bar

Genetics0.00

Brain cell0.50

Druggability1.00

Trial record0.96

Novelty0.49

Pathways0.20

viability · bar 0.550.43

Would flip the verdict

human genetics above 0.30 (Open Targets)
a Reactome pathway tied to known Alzheimer's biology

11 Oct, 16:43 UTC

Ledger #0012BELOW BAR

CDC25B

viability 0.45 is under the 0.55 bar

Genetics0.00

Brain cell0.50

Druggability0.70

Trial record1.00

Novelty0.83

Pathways0.20

viability · bar 0.550.45

Would flip the verdict

human genetics above 0.30 (Open Targets)
a Reactome pathway tied to known Alzheimer's biology

11 Oct, 16:36 UTC

Ledger #0011BELOW BAR

HFE

viability 0.48 is under the 0.55 bar

Genetics0.61

Brain cell0.35

Druggability0.50

Trial record0.20

Novelty0.49

Pathways0.55

viability · bar 0.550.48

Would flip the verdict

enrichment in a brain cell type we can culture

11 Oct, 16:33 UTC

Ledger #0010BELOW BAR

GRIN3A

viability 0.53 is under the 0.55 bar

Genetics0.00

Brain cell0.80

Druggability1.00

Trial record1.00

Novelty0.74

Pathways0.20

viability · bar 0.550.53

Would flip the verdict

human genetics above 0.30 (Open Targets)
a Reactome pathway tied to known Alzheimer's biology

11 Oct, 16:29 UTC

Ledger #0009BELOW BAR

CDK5R1

viability 0.42 is under the 0.55 bar

Genetics0.00

Brain cell0.50

Druggability0.70

Trial record1.00

Novelty0.65

Pathways0.20

viability · bar 0.550.42

Would flip the verdict

human genetics above 0.30 (Open Targets)
a Reactome pathway tied to known Alzheimer's biology

11 Oct, 16:24 UTC

Ledger #0008BELOW BAR

SLC6A3

viability 0.48 is under the 0.55 bar

Genetics0.00

Brain cell0.00

Druggability1.00

Trial record0.94

Novelty0.63

Pathways1.00

viability · bar 0.550.48

Would flip the verdict

human genetics above 0.30 (Open Targets)
enrichment in a brain cell type we can culture

11 Oct, 16:18 UTC

Ledger #0007BELOW BAR

BCHE

viability 0.45 is under the 0.55 bar

Genetics0.00

Brain cell0.80

Druggability1.00

Trial record0.82

Novelty0.10

Pathways0.55

viability · bar 0.550.45

Would flip the verdict

human genetics above 0.30 (Open Targets)

11 Oct, 16:09 UTC

Ledger #0006BELOW BAR

BCHE

viability 0.45 is under the 0.55 bar

Genetics0.00

Brain cell0.80

Druggability1.00

Trial record0.82

Novelty0.10

Pathways0.55

viability · bar 0.550.45

Would flip the verdict

human genetics above 0.30 (Open Targets)

11 Oct, 16:09 UTC

Ledger #0005BELOW BAR

ACHE

viability 0.32 is under the 0.55 bar

Genetics0.00

Brain cell0.50

Druggability1.00

Trial record0.20

Novelty0.00

Pathways0.55

viability · bar 0.550.32

Would flip the verdict

human genetics above 0.30 (Open Targets)

11 Oct, 16:03 UTC

Ledger #0004BELOW BAR

ACHE

viability 0.32 is under the 0.55 bar

Genetics0.00

Brain cell0.50

Druggability1.00

Trial record0.20

Novelty0.00

Pathways0.55

viability · bar 0.550.32

Would flip the verdict

human genetics above 0.30 (Open Targets)

11 Oct, 16:01 UTC

Ledger #0003BELOW BAR

CDK5

viability 0.37 is under the 0.55 bar

Genetics0.00

Brain cell0.50

Druggability0.90

Trial record1.00

Novelty0.17

Pathways0.20

viability · bar 0.550.37

Would flip the verdict

human genetics above 0.30 (Open Targets)
a Reactome pathway tied to known Alzheimer's biology

11 Oct, 15:54 UTC

Ledger #0002BELOW BAR

PSEN2

viability 0.50 is under the 0.55 bar

Genetics0.20

Brain cell0.50

Druggability0.90

Trial record0.64

Novelty0.19

Pathways1.00

viability · bar 0.550.50

Would flip the verdict

human genetics above 0.30 (Open Targets)

11 Oct, 15:39 UTC

Ledger #0001BELOW BAR

PSEN2

viability 0.50 is under the 0.55 bar

Genetics0.20

Brain cell0.50

Druggability0.90

Trial record0.64

Novelty0.19

Pathways1.00

viability · bar 0.550.50

Would flip the verdict

human genetics above 0.30 (Open Targets)

11 Oct, 15:39 UTC