$ALZ
OpenAlz
Dead-End Ledger
Ledger #0017BELOW BAR

GSK3B

viability 0.42 is under the 0.55 bar

Genetics0.00
Brain cell0.50
Druggability1.00
Trial record1.00
Novelty0.40
Pathways0.20

viability · bar 0.550.42

Would flip the verdict

  • human genetics above 0.30 (Open Targets)
  • a Reactome pathway tied to known Alzheimer's biology
seal a0ab8bfe4b#0016sealed ✓

11 Oct, 17:09 UTC

Ledger entry #0017

GSK3B was logged as a dead end: viability 0.42 is under the 0.55 bar. The seal is a SHA-256 digest of every field in this entry plus the seal of the entry before it, so changing or deleting any entry would visibly break the chain.

seal
a0ab8bfe4b37e51a95a1c0779cb6c580697467aee66c43a6d162989275287f02
chained to (previous seal)
3763ff2b195486cf1aa1f3f55610c3ba05ec4091971c9dce98d6e264f9770b12
re-computed by your browser
matches ✓
next entry chains to this seal
yes ✓
#0016#0018 Scout a target