$ALZ
OpenAlz
Dead-End Ledger
Ledger #0018BELOW BAR

CDKN2B

viability 0.46 is under the 0.55 bar

Genetics0.36
Brain cell0.35
Druggability0.30
Trial record1.00
Novelty0.74
Pathways0.20

viability · bar 0.550.46

Would flip the verdict

  • enrichment in a brain cell type we can culture
  • a Reactome pathway tied to known Alzheimer's biology
  • a druggable pocket, ligand or antibody route
seal 2c5ffb0c88#0017sealed ✓

11 Oct, 17:18 UTC

Ledger entry #0018

CDKN2B was logged as a dead end: viability 0.46 is under the 0.55 bar. The seal is a SHA-256 digest of every field in this entry plus the seal of the entry before it, so changing or deleting any entry would visibly break the chain.

seal
2c5ffb0c88c7f8d3c37ffe62c544b718db503fed3690be5101a9aa2a7dc6f67a
chained to (previous seal)
a0ab8bfe4b37e51a95a1c0779cb6c580697467aee66c43a6d162989275287f02
re-computed by your browser
matches ✓
next entry chains to this seal
yes ✓
#0017#0019 Scout a target