$ALZ
OpenAlz
Dead-End Ledger
Ledger #0003BELOW BAR

CDK5

viability 0.37 is under the 0.55 bar

Genetics0.00
Brain cell0.50
Druggability0.90
Trial record1.00
Novelty0.17
Pathways0.20

viability · bar 0.550.37

Would flip the verdict

  • human genetics above 0.30 (Open Targets)
  • a Reactome pathway tied to known Alzheimer's biology
seal 94bd91cd5d#0002sealed ✓

11 Oct, 15:54 UTC

Ledger entry #0003

CDK5 was logged as a dead end: viability 0.37 is under the 0.55 bar. The seal is a SHA-256 digest of every field in this entry plus the seal of the entry before it, so changing or deleting any entry would visibly break the chain.

seal
94bd91cd5d9743d9511d2a67462c65ef5a7d508ba2f414b610ef426872c379b2
chained to (previous seal)
cbd53f268b81cfcdaa9a247ed5e2887562d923fd3adc486a63bc792414345df4
re-computed by your browser
matches ✓
next entry chains to this seal
yes ✓
#0002#0004 Scout a target