$ALZ
OpenAlz
Dead-End Ledger
Ledger #0009BELOW BAR

CDK5R1

viability 0.42 is under the 0.55 bar

Genetics0.00
Brain cell0.50
Druggability0.70
Trial record1.00
Novelty0.65
Pathways0.20

viability · bar 0.550.42

Would flip the verdict

  • human genetics above 0.30 (Open Targets)
  • a Reactome pathway tied to known Alzheimer's biology
seal c5f4205bd1#0008sealed ✓

11 Oct, 16:24 UTC

Ledger entry #0009

CDK5R1 was logged as a dead end: viability 0.42 is under the 0.55 bar. The seal is a SHA-256 digest of every field in this entry plus the seal of the entry before it, so changing or deleting any entry would visibly break the chain.

seal
c5f4205bd11776755b7b4c48ae348adcd0da05228b1125e6321e07cb7525da4b
chained to (previous seal)
5f964080eebddb10e724317ec28b15f5ec0f998f35a04c2c1f6c52ddd6173907
re-computed by your browser
matches ✓
next entry chains to this seal
yes ✓
#0008#0010 Scout a target